Last edited by Fet
Thursday, July 23, 2020 | History

4 edition of Design and analysis of vaccine studies found in the catalog.

Design and analysis of vaccine studies

M. Elizabeth Halloran

Design and analysis of vaccine studies

by M. Elizabeth Halloran

  • 182 Want to read
  • 30 Currently reading

Published by Springer in New York .
Written in English

    Subjects:
  • Statistical methods,
  • Research Design,
  • Methods,
  • Drug Evaluation,
  • Research,
  • Vaccines,
  • Epidemiology,
  • Case-control method,
  • Statistics as Topic,
  • Clinical Trials as Topic

  • Edition Notes

    Includes bibliographical references (p. 361-379) and index.

    StatementM. Elizabeth Halloran, Ira M. Longini, Jr., Claudio J. Struchiner
    SeriesStatistics for biology and health, Statistics for biology and health
    ContributionsLongini, Ira M., Struchiner, Claudio J.
    Classifications
    LC ClassificationsQR189 .H35 2010
    The Physical Object
    Paginationxviii, 387 p. :
    Number of Pages387
    ID Numbers
    Open LibraryOL25000785M
    ISBN 100387403132, 0387686363
    ISBN 109780387403137, 9780387686363
    LC Control Number2009938829
    OCLC/WorldCa436030925

    seminal role in our meta-analysis of current influenza vaccines published in The Lancet Infectious Diseases. He also mentored us on the critical aspects of study design for determining influenza vaccine efficacy and effectiveness. Pritish Tosh, MD, of the Mayo Clinic has spent the past 8 months as a research fellow at CIDRAP;File Size: 2MB.   This was a very interesting book discussing the likelihood that an adjuvant (squalene)addd to the Anthrax vaccine is the cause of gulf war syndrome. It makes a very good case for it. For example, dozens of studies in multiple counties have shown squaleneinjected into animals cause autoimmune diseases (as does Gulf War Syndrome)/5.

    Design of a cohort study to evaluate influenza vaccine effectiveness against laboratory-confirmed influenza. “Health care-seeking behavior” can introduce bias because (1) the outcome is usually confirmed only after the subjects visit medical institutions and (2) vaccinees and non-vaccinees are inherently different in the likelihood of their Cited by: Emphasis should be placed on confidence intervals, rather than point estimates, of vaccine effectiveness. Case-control studies are a useful approach for evaluating vaccine effectiveness; however careful attention must be paid to the collection, analysis and presentation of the data in order to best inform evidence-based vaccine by: 3.

    Vaccine Safety: Examine the Evidence. The safety and effectiveness of vaccines are under constant study. Because vaccines are designed to be given routinely during well-child care visits, they must be extraordinarily safe. Safety testing begins as soon as a new vaccine is contemplated, continues until it File Size: KB. Authoritative and practical, Vaccine Design: Methods and Protocols, Volume 1: Vaccines for Human Diseases aims to ensure successful results in the further study of this vital field. Discover the Author: Sunil Thomas.


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Design and analysis of vaccine studies by M. Elizabeth Halloran Download PDF EPUB FB2

“Any book targeting a wide audience with technical material confronts the problem of balancing rigor with accessibility.

Design and Analysis of Vaccine Studies largely succeeds at this task. A cursory reading of this book will give readers an understanding of the concepts and techniques needed to successfully analyze vaccine studies .Cited by:   Design and Analysis of Vaccine Studies largely succeeds at this task.

A cursory reading of this book will give readers an understanding of the concepts and techniques needed to successfully analyze vaccine studies, while those who take the time to master Design and analysis of vaccine studies book technical material will be rewarded with a deep understanding of vaccine studies and Author: Derek A.

Cummings, Justin Lessler. “Any book targeting a wide audience with technical material confronts the problem of balancing rigor with accessibility. Design and Analysis of Vaccine Studies largely succeeds at this task. A cursory reading of this book will give readers an understanding of the concepts and techniques needed to successfully analyze vaccine studies .Manufacturer: Springer.

"Any book targeting a wide audience with technical material confronts the problem of balancing rigor with accessibility. Design and Analysis of Vaccine Studies largely succeeds at this task.

A cursory reading of this book will give readers an understanding of the concepts and techniques needed to successfully analyze vaccine studies .2/5(1). The book covers many different vaccine effects, including vaccine efficacy for susceptibility, for disease, for post-infection outcomes, and for infectiousness.

The book includes methods for evaluating indirect, total and overall effects of vaccination programs in populations. “Any book targeting a wide audience with technical material confronts the problem of balancing rigor with accessibility.

Design and Analysis of Vaccine Studies largely succeeds at this task. A cursory reading of this book will give readers an understanding of the concepts and techniques needed to successfully analyze vaccine studies.

Get this from a library. Design and analysis of vaccine studies. [M Elizabeth Halloran; Ira M Longini; Claudio J Struchiner] -- Widespread immunization has many different kinds of effects in individuals and populations, including in the unvaccinated individuals.

The challenge is. As well as being a reference for the design, analysis, and interpretation of vaccine studies, the text covers all design and analysis stages, from vaccine development to post-licensure surveillance, Read more.

Online base book. Active Networks: IFIP TC6 6th International Working Conference, IWANLawrence, KS, USA, October, Revised Papers (Lecture Notes in Computer. Case-control studies are commonly used to evaluate effectiveness of licensed vaccines after deployment in public health programs.

Such studies can provide policy-relevant data on vaccine performance under 'real world' conditions, contributing to the evidence base to support and sustain introduction of new by: Design and Analysis of Vaccine Studies (M. Halloran, I. Longini Jr.

and C. Struchiner) Neal Alexander A SAS/IML Companion for Linear Models (J. Perrett) James E. Gentle Introducing Mont Author: Neal Alexander. In this review we elaborate on recent achievements that facilitate rational vaccine design. There are many visions on the expected impact of reverse vaccinology, epitope prediction, structural vaccinology, systems vaccinology, and personalized medicine on the rational design of effective vaccines [3], [5], [6], [].

Mary Elizabeth (Betz) Halloran is an American biostatistician who works as a professor of biostatistics, professor of epidemiology, With Longini and Claudio J. Struchiner, she is a co-author of the book Design and Analysis of Vaccine Studies (Springer, ). This text provides a practical guide providing step-by-step protocol to design and develop vaccines.

Chapters detail protocols for developing novel vaccines against infectious bacteria, viruses, fungi, and parasites for humans and animals. Volume 1: Vaccines for Human Diseases has an introductory. The book covers many different vaccine effects, including vaccine efficacy for susceptibility, for disease, for post-infection outcomes, and for infectiousness.

The book includes methods for evaluating indirect, total and overall effects of vaccination programs in populations. Design and Analysis of Vaccine Studies的书评. The book has been divided into two parts. The first part reviews the technologies and approaches used to identify, generate and test new vaccines.

Topics include: new strategies to identify protective antigens, generation of improved adjuvants, use of alternative immunization routes, improving vaccine safety, and finding and establishing the correlates of protection.

The primary analysis estimates total vaccine effectiveness, which measures the individual-level benefit of the vaccine resulting from the combination of direct and indirect vaccine effects.

If data collection are expanded to include non-participants, the trial can generate estimates of Author: Natalie E. Dean, Pierre-Stéphane Gsell, Ron Brookmeyer, Victor De Gruttola, Christl A. Donnelly, Chr. At the Vaccine Research Center (VRC), we conduct clinical research studies that are vital to developing vaccines that ease human suffering, can potentially prevent a pandemic, and in many cases, save lives.

We work closely with volunteers in our clinical studies to evaluate vaccines against diseases such as HIV/AIDS, Ebola, flu, and others.

How to Cite. Alexander, N. (), Design and Analysis of Vaccine Studies by HALLORAN, M. E., LONGINI JR., I. M., and STRUCHINER, C. Biometrics, – doi.

Design and Analysis of Vaccine Studies: M. Elizabeth Halloran: Hardcover: Biostatistics book. "Any book targeting a wide audience with technical material confronts the problem of balancing rigor with accessibility. Design and Analysis of Vaccine Studies largely succeeds at this task.

A cursory reading of this book will give readers an understanding of the concepts and techniques needed to successfully analyze vaccine studies .Book Edition: Ed.Vaccine trials may take months or years to complete, since a sufficient time period must elapse for the subjects to react to the vaccine and develop the required antibodies.

Vaccine Trial Regulation Errors. Poliomyelitis, a viral disease, has the potential to damage the .Vaccine Research Applications for Gene Synthesis. Gene synthesis is routinely used in vaccine research, from basic studies in immunology and microbiology that are critical for rational vaccine design, to cutting-edge DNA vaccine drug development efforts.